Seven years have passed since Dr. Hannibal Lecter (Anthony Hopkins) escaped from custody. The doctor is now at large in Europe. Mason Verger (Gary Oldman) remembers Lecter too, and is obsessed with revenge. Verger was Dr. Lecter's sixth victim, and though horribly disfigured, has survived. Verger realizes that to draw the doctor into the open, he must use someone as bait: Clarice Starling (Julianne Moore).